A significant disconnect persists between the knowledge produced by randomized controlled trials (RCTs) and its consistent implementation in clinical practice. Addressing this gap necessitates targeted advancements across several key domains. The annual SCTO Symposium provides a platform for sharing experiences and facilitating discussions that allow for the identification of action items such as training needs, the adaptation of processes, and potential legislative gaps. Furthermore, the ethical and regulatory landscape must adapt to facilitate the convergence of clinical research and routine healthcare, without compromising stringent patient safety measures and oversight.
Additionally, study designs should become more flexible and reflective of real-world conditions to ensure trial outcomes are readily translatable to practical settings. The development of a strong data infrastructure is also crucial, enabling fluid data exchange and analysis between clinical research and healthcare systems.
Lastly, aligning the objectives of clinical trial organizations and healthcare delivery systems is vital for promoting collaboration and encouraging the adoption of research findings into daily clinical routines. Collectively, these points underscore the existing challenges and suggest a potential pathway for better integrating clinical research with healthcare delivery, ultimately striving to improve patient outcomes and close the knowledge-to-practice divide.