Small G proteins in cellular signalling and disease 2025

Small G proteins from the Ras superfamily are key regulators of numerous cell signaling pathways and influence a wide range of biological processes. When these proteins or their signaling networks are disrupted, it can lead to diseases such as cancer, genetic disorders, and infections caused by pathogens. Ras, the first identified member of this superfamily, is a major driver of approximately 20% of human cancers, making its inhibition a critical global research focus.

This meeting will explore the latest research across all five families of small G proteins to spark new ideas, collaborations, and scientific approaches. Topics will include the Ras family’s role in cell proliferation, the Rho family’s control of cytoskeletal dynamics, the Arf and Rab families’ involvement in vesicle transport, and Ran’s function in nuclear trafficking.

Leading experts in the field will present recent breakthroughs in understanding how small G proteins function at the molecular level. The conference will foster connections between established researchers and early-career scientists, offering a dynamic platform for sharing new findings and networking opportunities.